Somatic Cell Nuclear Transfer. Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. John gurdon was the first to demonstrate that animals could be cloned from differentiated frog somatic cells by scnt.
Nuclear transfer that involves the transfer of the nucleus from a donor cell into an oocyte or early embryo from which the chromosomes have been removed was considered first as a means of assessing changes during development in the ability of the nucleus to control development. Many factors affecting clonin. The technique revolutionized the field regenerative medicine and paved way to engineer stem cells for biomedical applications.
Animal cloning the somatic cell nuclear transfer scnt cloning became a buzzword when dolly the first mammalian species was born from the nuclear transfer of fibroblasts taken from adult sheep.
Somatic cell nuclear transfer scnt technique in which the nucleus of a somatic body cell is transferred to the cytoplasm of an enucleated egg an egg that has had its own nucleus removed. Once inside the egg the somatic nucleus is reprogrammed by egg cytoplasmic factors to become a zygote fertilized egg nucleus. Somatic cells donate their nuclei which scientists transplant into eggs after removing their nucleuses enucleated eggs. In some cases the transferred nucleus successfully controls.