Melanin Transfer From Melanocyte To Keratinocyte. Model of melanin transfer and the mc organelle in human skin keratinocytes. Mesh terms animals calcium metabolism cell line tumor cell.
For decades cellular mechanisms underlying pigment transfer have remained enigmatic. Analogy of melanocytes to neuronal cells and cells of. B direct membrane fusion between melanocytes and keratinocytes establishing.
The epithelial cells called keratinocytes found in the stratum germinativum surround this part of the melanocyte and engulf the melanin using endocytosis.
Melanin is produced within melanosomes which later migrate into the melanocytes dendrite tips using myosin v filaments 1 and a dynein motor 2in addition several mechanisms for melanosome transfer from the dendrite tips into the keratinocytes have been suggested including phagocytosis release of melanosomes into intercellular spaces followed by endocytosis direct. Melanin transfer from melanocytes to keratinocytes and subsequent accumulation in the supranuclear region is a critical process in skin pigmentation and protection against uvr. Four different models are proposed to explain the transfer of melanin from melanocytes to keratinocytes. A cytophagocytosis of melanocyte dendrite tips by keratinocytes.