Igg Placental Transfer. However factors that modulate the placental transfer of igg remain largely undefined. Zugaib department of obstetrics and gynecology sao paulo university medical school sao paulo brazil.
Treatment with a monoclonal antibody able to block igg binding to the fcrn ameliorated the severity of symptoms in experimental animal models of myasthenia gravis. Igg1 is the most efficiently transported subclass and igg2 the least. Fcrn is an established transepithelial transporter of igg and may be involved in the transport of igg across the trophoblast barrier in humans.
Placental igg transfer begins during the first trimester but increases exponentially during pregnancy with the majority of transfer occurring during the third trimester fouda et al 2018.
This crossing is mediated by fcrn expressed on syncytiotrophoblast cells. In fact infant cord blood concentrations of maternal igg can well exceed maternal igg serum concentrations by delivery in full term pregnancies 25 27. This crossing is mediated by fcrn expressed on syncytiotrophoblast cells. Igg is the only antibody class that significantly crosses the human placenta.